Molecular Pathology of Cervical Cancer
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Molecular Pathology of Cervical Cancer |
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| Region | Incidence Overall | Incidence Males | Incidence Females | Deaths Overall | Deaths Males | Deaths Females |
|---|---|---|---|---|---|---|
| USA | 12200 | 12200 | 4210 | 4210 | ||
| Source: American Cancer Society. Cancer Facts & Figures 2010. Atlanta: American Cancer Society; 2010 | ||||||
| Affected Protein | Pathway | Sub-Type | Ethnicity | Stage | Frequency (%) | Gene Amplification | Activating Mutation | Inactivating Mutation | Deletion | Promoter Hypermethylation | Comment | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EGFR (ErbB-1 receptor) | Receptor Tyrosine Kinase Signaling |
primary cervical cancers | 64% | overexpression by immunohistochemistry | ||||||||
| p53 | p53 Tumor Suppressor Pathway |
7% | ||||||||||
| Pi3-kinase | PI3-Kinase Signaling |
invasive cervical carcinomas | 8% | the mutation rate was significantly higher in patients older than 60 years | ||||||||
| PTEN | PI3-Kinase Signaling |
15% | ||||||||||
| PTEN | PI3-Kinase Signaling |
high-grade cervical intraepithelial neoplasia (CIN-H) | 40% | |||||||||
| PTEN | PI3-Kinase Signaling |
squamous cell carcinoma (SCC) | 58% |
